Recurrent ON occurs in association with MOG antibodies distinct from neuromyelitis optica and multiple sclerosis, and may require steroid-based immunosuppression to maintain remission. However, her optic neuritis was better accounted for by MOG-IgG-associated optic neuritis, and testing for this was not available at her initial presentation 8 years prior.
MOG OPTIC NEURITIS SERIES
Two patients in our series had multiple relapses.
MOG OPTIC NEURITIS FREE
She has been relapse free on low-dose steroids and mycophenolate for 2 years. Her initial optic neuritis resulted in a diagnosis of Sjogren’s syndrome, and she indeed had clinical and laboratory evidence for this condition. Although MOG-AD patients may develop myelitis, encephalitis and seizures, it has been reported that 30 of MOG-AD patients with recurrent optic neuritis may not show any other neurological symptoms. She responded to intravenous and long-term steroids combined with mycophenolate mofetil, but relapsed when steroids were discontinued. However ON in these diseases has some different features. Background: Optic neuritis (ON) is a main presenting symptom of neuromyelitis optica (NMO) and multiple sclerosis (MS). While the function of this glycoprotein is not exactly known, MOG is a target of the immune system in this disease. Objective: To determine the relationship between immunological parameters (NMO-Ab, OCB, antiMOG-Ab) and clinical features and visual functions in NMO/NMOSD and MS patients with ON. Myelin oligodendrocyte glycoprotein (MOG) is a protein that is located on the surface of myelin sheaths in the central nervous system. AQP4 antibodies were negative but MOG antibodies were positive. MOG antibody disease (MOGAD) is a neurological, immune-mediated disorder in which there is inflammation in the optic nerve, spinal cord and/or brain. On examination on admission, visual acuity was noted to be 20/30 on the left and visual evoked potentials were prolonged bilaterally, but all other neurological investigations including screening tests for infections and vasculitis were unremarkable. We report a case of recurrent ON with MOG antibodies in a South Asian patient.Ī 50-year-old Sri Lankan female with a previous history of 2 episodes of steroid-responsive ON presented with a 20/120 visual impairment of her right eye. The presence of peripapillary hemorrhage or extreme edema of the optic disc. A proportion of these patients have antibodies against myelin oligodendrocyte glycoprotein (MOG). Optical disc edema (between 86 of sufferers with NO-MOG and 5-33 with NO-AQP4). Optic neuritis (ON) can be the first manifestation of autoimmune central nervous system diseases such as multiple sclerosis and neuromyelitis optica, but it can also occur as an isolated monophasic or relapsing disease. Moreover, in MOG-Abpositive optic neuritis patients, edema and meandering of the optic nerve, as well as strong contrast enhancement in orbital tissues around the optic nerve, were observed.
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